home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Arsenal Files 6
/
The Arsenal Files 6 (Arsenal Computer).ISO
/
health
/
med9603.zip
/
M9630215.TXT
< prev
next >
Wrap
Text File
|
1996-02-27
|
2KB
|
37 lines
Document 0215
DOCN M9630215
TI Sjogren's syndrome.
DT 9603
AU Fox RI; Department of Rheumatology, Scripps Clinic and Research;
Foundation, La Jolla, CA 92037, USA.
SO Curr Opin Rheumatol. 1995 Sep;7(5):409-16. Unique Identifier : AIDSLINE
MED/96089426
AB The literature published over the past year on Sjogren's syndrome is
reviewed, including epidemiology, genetic, environmental, and clinical
features. The criteria for the classification of Sjogren's syndrome
remain controversial, potentially leading to confusion in clinical
practice and in research publications. Dryness of the eyes and mouth can
result from either interruption of the neurovascular innervation of the
glands or from any infiltrative process that affects the ability of the
glands to secrete. Recent studies have demonstrated that sicca symptoms
also can result from autonomic neuropathy in patients with diabetes,
multiple sclerosis, or systemic lupus erythematosus. It is suggested
that the term Sjogren's syndrome be used to describe one subset of
patients with sicca symptoms who exhibit particular major
histocompatibility complex antigens, the presence of T cell lymphoid
infiltrates on glandular biopsy, and specific autoantibodies in their
sera. Even using these restrictive criteria for classification, no
single environmental factor has been shown as necessary or sufficient
for pathogenesis. Recent studies on Epstein-Barr virus have indicated a
novel deleted virus in some Chinese Sjogren's syndrome patients. Other
patients with sicca symptoms and autoimmune features may have infections
with HIV or hepatitis C virus.
DE Animal Disease Models, Animal Environment Human Major
Histocompatibility Complex/GENETICS Sjogren's
Syndrome/*COMPLICATIONS/*ETIOLOGY/THERAPY JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).